^{14th International Conference on} Clinical Nutrition July 27-29, 2017 Rome, Italy

Biography:

François J Roman co-founded Amylgen in 2009. Previously, he served as the VP of R&D at Euroscreen, Belgium from 2004. Prior to this position, he had held various Drug Discovery management positions at Pfizer PGRD France, Parke-Davis France, Jouveinal Laboratoires, and Laboratoires Servier, where he started his career in 1977. He holds a PhD in Biochemistry from the University of Paris VI, France and has more than 40 publications and 35 patents

Abstract:

Acting as a CRO, Amylgen has developed a unique and proprietary know-how on rodent models of Alzheimer’s disease and other CNS pathologies. We are working more and more with companies involved in nutrition field. We have set up new models allowing to reproduce brain ageing process. In particular, senescence accelerated mice (SAM): the P8 sub strain (SAM-P8) has a markedly shortened life span when compared to the R1 sub strain (SAM-R1). Mitochondrial dysfunction, oxidative stress, and increased somatic DNA mutation rate all appear to be involved in the mechanisms responsible for the accelerated ageing process. Another model of ageing is the D-galactose (DG) induced ageing mouse model. Chronic treatment with DG leads to the acceleration of senescence. Animals show cognitive dysfunction, neurologic impairment associated with the increases of brain oxidative stress, cholinergic degeneration, impairment of synaptic plasticity and neurogenesis, altered expression of amyloid-beta metabolism-associated molecules, reactive gliosis and neuroinflammation. Finally we propose models in young rats or mice allowing to test the effects of products on learning capacity in normal animals or in animals with a learning deficit produced by a prenatal stress. Behavior tests are available for exploring the various aspects of brain health during ageing. A large panel of memory tests allows exploring and analyzing many aspects of memory. Tests for evaluating depression and anxiety are also available. Biochemical, neurochemical and histological analyses are performed to translate health status of ageing brain such as oxidative stress, mitochondrial function, synaptic function, cholinergic system integrity. Neuroinflammation is explored by the study of astrocyte and microglia activation. The neurogenesis potential of the product may also be determined. Amylgen’s platform helps its customers characterizing their products, allowing an attractive communication about their properties and also preparing further clinical studies for obtaining a health claim from FDA or EFSA

Biography:

Hu Liu, Ph.D., School of Pharmacy, Memorial University of Newfoundland, ST. John's, NL, CANADA Following his B.Sc. (Pharmacy) in 1982 from Beijing Medical College and M.Sc. (Pharmaceutical chemistry) degrees from Beijing Medical University (now Peking University) in Beijing, China, Dr. Liu obtained his Ph.D. degree in lipid and lipoprotein biochemistry from the University of Alberta in 1993 in Canada.  He then did his post-doctoral training in pharmacology and medicinal chemistry at the University of Michigan, Ann Arbor MI, USA.  In 1994, Dr. Liu joined School of Pharmacy, Memorial University, and he is a full professor. From 1999 to 2004, Dr. Liu was a recipient of the Career Award in Health Sciences sponsored by Medical Research Council of Canada (MRC) which was renamed as Canadian Institutes of Health Research (CIHR) and the Health Sciences Foundation of Canada's Research Based Pharmaceutical Companies (Rx&D-HRF). In 2000, he was awarded with the AstraZeneca New Investigator Research Award by the Association of Faculties of Pharmacy of Canada (AFPC).  He served as an internal grants reviewer for the Pharmaceutical Sciences Committee of CIHR.  In 2002, together with three colleagues Dr. Liu founded the former North Atlantic BioPharma Inc., a biotech company focused on developing marine based pharmaceuticals. Dr. Liu was the President and Chief Scientific Officer of the company.  His research activities were funded by many agencies including MRC/CIHR, Banting Foundation, National Research Council of Canada (NRC), Atlantic Canada Opportunities Agency (ACOA) and International Science and Technology Partnership Canada (ISTPCanada).  Dr. Liu's research interests include: development of drugs and drug delivery systems in the areas of cancer, cardiovascular disease and inflammation in addition to cold ocean derived pharmaceuticals

Abstract:

As the Inuit people spread across the Arctic and Greenland, they ate a lot of fatty meat from seals, whales and fish. However, the Inuit didn’t have a lot of heart attacks. In the 1970s, Danish scientists studying Inuit diets proposed that ω-3 fatty acids were cardio-protective. In the North Atlantic Ocean between Greenland and Eastern Canada, there are over 10 million Harp seals. Each year about 200,000 seals are harvested to maintain the balance of ecosystem. It is believed that Harp seal oil is the best source of ω-3 lipids and has several superior characteristics over fish oil. It contains all cis-docosahexaenoic acid (DHA, 22:6 ω-3), eicosapentaenoic acid (EPA, 20:5 ω-3) and docosapentaenoic acid (DPA, 22:5 ω-3), while fish oil contains only EPA and DHA. It is found that ω-3 fatty acids in seal oil are mostly esterified at the triacylglyceride sn-1,3 (outer) positions, which makes them the preferred substrates for human lipases. Fish are aquatic vertebrates that are typically cold-blooded and are described as non-tetrapod chordates. ω-3 fatty acids in fish oil are distributed mainly at the sn-2 position of triacyglycerides. Such a positional distribution of ω-3 fatty acids in the glycerol backbone makes them poor substrates for human lipases which normally hydrolyze fatty acylglycerol ester bonds at the sn-1 and sn-3 positions of triacylglycerides. In addition seal oil is extracted and processed at low temperatures (20-50°C), resulting in very little oxidation and formation of trans-fatty acids. On the other hand, fish oil is extracted by steam (100°C) which results in significantly elevated levels of both oxidized- and trans-lipids. We hypothesized that seal oil emulsions can be used in the total parenteral nutrition (TPN) regiments for hospitalized patients who require intravenous infusion of nutrients, especially post-surgical patients, patients experiencing early stage of sepsis/systematic inflammatory response syndrome (SIRS), patients with inflammatory bowel diseases (IBD), and patients with autoimmune diseases. A study using an endotoxemia rat model (to mimic septic conditions) demonstrated the potent anti-inflammatory effects of seal oil

Biography:

Zach M Bush is one of the few triple Board Certified Physicians in the country, with specialties in Internal Medicine, Endocrinology and Metabolism, and Hospice/Palliative Care. His achievements include award-winning cell biology, clinical care, and medical education. He is the Founder and Director of Revolution Health Center in Charlottesville, Virginia, and is the CEO of Biomic Sciences - the team that has brought forth the novel science and product line of Restore

Abstract:

Over the last 10 years, there has been an explosion of basic science data that has revealed a link between the intestinal microbiome and systemic disease in the human host. The lack of some species or the presence of other bacterial species has been shown to correlate with the occurrence of metabolic diseases, immune dysfunction, and many cancers. This correlation has radically changed the landscape of anti-aging and cancer research, and broadened the potential adjuvant therapies and interventions to prevent and reverse chronic disease in the future. However, there has been a lack of understanding of the mechanisms by which dysbiosis causes systemic inflammatory and metabolic disarray. This lecture demonstrates how massive changes in our farming and soil ecology practices of the last 30 years have impacted the demographic and geographic distributions of cancer death. Furthermore, we demonstrate how these farming practices contribute to chronic inflammation and metabolic collapse within the American population, offering new molecular insights into the direct and indirect mechanisms by which dysbiosis in our macro and micro-environments may mediate systemic disease. We show here the biologic effects of a recently discovered family of bacterial metabolites that constitute a vast array of carbon-based redox signaling molecules. We show that these molecules can regulate and maintain the macrostructures of the extracellular matrix and the human immune system, and also directly mediate the differential production of mitochondrial reactive oxygen species and apoptosis in healthy and cancerous cell types. This breakthrough new science offers a new model for the ecology of human health, pathogenesis of disease, and potential nutritional adjuvant therapies of the future

Biography:

Robert Posner (MD) is a Diplomate of the American Board of Internal Medicine and the Founder of the medically supervised Serotonin-Plus Weight Control Program. He is a former US Navy Physician and interviewed to be President Reagan’s Physician position before opting for private practice. He researched, developed and patented oral serotonin supplementation and this became the marquee feature of the SP Program that has now helped tens of thousands of patients to lose weight safely and effectively across the United States. Over 100 board certified physicians across America have brought the SP Program and products into their practices. He is the author of “The Serotonin Solution to Never “Dieting” Again” and he has lectured at medical meetings across the USA and now Europe. He has developed new, patented serotonin products and the first one, SeroPro, the Serotonin Solution for Mood Enhancement launched in April, 2017. In 2018, he will come out with serotonin-based supplements for menopause, PMS, blood sugar and sexual dysfunction

Abstract:

Serotonin (5-HT) is a naturally occurring amine neurotransmitter made inside the body from the amino acid, tryptophan.  There are 7 different classes of serotonin receptors and different subclasses of each receptor. Serotonin imbalance has been linked to depression, anxiety, migraine headaches, bipolar disorder, diabetes, cancer and carbohydrate cravings.  There are many prescription medications that work indirectly via serotonin mechanisms such as antidepressants and migraine headache treatments.  Concerning weight control there have been prescription medications and dietary supplements that work to reduce appetite and cravings indirectly via serotonin mechanisms. Patented oral serotonin delivery has been used at the medically supervised Serotonin-Plus Weight Loss Centers.  Over 24,000 patients have been treated with an average weight loss of 30 pounds in females and 40 pounds in males in the 12-week protocol.  The co-morbidities associated with obesity, such as diabetes, hypertension, hypercholesterolemia and others have been impacted significantly by the Serotonin-Plus Program and the patented serotonin supplements. The mechanism of action, studies using the supplement and clinical experience will be discussed.  The science of serotonin and applications for helping people control weight long term by reducing carbohydrate cravings  will be detailed. In conclusion, combining oral serotonin supplementation with a high protein/low carbohydrate dietary approach and supportive visits to instill behavioral modification result in aggressive weight control and the immediate lowering of diabetes risk, need for diabetes medication, lowering of blood pressure and an overall reduction of the need for medications to treat the co-morbidities of obesity

Biography:

Lisa Pawloski is Chair and Professor in the Department of Nutrition and Food Studies. She is an expert in childhood obesity and biocultural aspects of health and nutrition among children, adolescents, and young adults. As a Fulbright Scholar in 1997, she examined the nutritional status of adolescent girls from the Segou Region in Mali, West Africa to explore factors impacting malnutrition in that region. Her current interests involve exploring the biocultural, geographic, and social determinants of obesity in transitional countries. She has most recently worked and conducted research in Nicaragua, Thailand, Chile, Iraq, and Costa Rica

Abstract:

Public health challenges in low-income countries often focus on issues of undernutrition, however, as countries transition, we often see a trend of increasing obesity and chronic diseases. One specific region which has undergone recent significant economic transition is the Autonomous Region of Kurdistan. Few studies have examined adult populations here, and none have explored related geographic components. Thus this paper presents nutritional status and geographic data collected from 1023 adult women aged 18 to 63 years working/studying at two universities in Erbil, Kurdistan. Nutritional status data included height, weight, body mass index, waist/hip circumference and percent body fat. Geographic data were collected by asking participants to locate their residence on large scanned maps which were georeferenced to known GIS layers of Erbil and then digitized. The local Getis-Ord spatial clustering statistic was used to identify spatial clusters of high and low BMI values. Indicators of underweight were found in 3.4% of the sample and 44% were found to be either overweight or obese. Spatial cluster analysis found a persistent cluster of low BMI values in the southwest quadrant of the city over a range of critical distances. Clusters of high BMI values were discernible across the central and eastern areas of the city, but varied with critical distances. These data suggest higher BMI to be associated with wealthier neighborhoods within Erbil. The findings are significant in that they represent one of the first descriptive and geographic analyses of the nutritional situation among women in Erbil, Kurdistan

Biography:

Jean-Claude Lavoie is Associated Professor in departments of Nutrition and Paediatrics of Université de Montréal where he has completed his PhD in 1998. He has published more than 90 papers in reputed scientific journals. His research works are funded primarily by the Canadian Institutes of Health Research. His research interest focuses on the impact of parenteral nutrition components on redox homeostasis in preterm infants in relation to chronic lung diseases such as bronchopulmonary dysplasia, energy metabolism and epigenetic modulator of chronic diseases observed in adults

Abstract:

Introduction: Peroxides contaminating parenteral nutrition (PN) are associated with oxidation of redox potential of glutathione in blood of preterm newborns (<30 weeks gestation) and in lungs of animal model of neonatal PN. These oxidized redox and peroxides are associated to bronchopulmonaria dysplasia in preterm newborns and induce loss of alveoli by apoptosis in animals. Glutathione detoxifies peroxides and normalises redox potential. However, glutathione is low in preterm newborns. Glutathione is derived from liver where methionine is transformed in cysteine of which availability limits the glutathione synthesis. Peroxides from PN inhibit the methionine adenosyltransferase, the first enzyme leading to cysteine. Thus, premature infants have a limited capacity to detoxify peroxides.

Hypothesis: Addition of glutathione in PN compensates for the low hepatic capacity to supply glutathione, and consequently preserves the lung integrity.

Method: At 3 days of life, guinea pigs (N=55) received PN enriched with glutathione (0, 75, 200, 270, 440, 600, 650, 1065 nmol GSSG/d/kg). After 4 days, lungs were determined for GSH, GSSG, redox potential and alveoli (number of intercepts between a line (1 mm) and histological structures).

Results: The results of the study were as follows: redox: doses 0-270 = -209±1; doses 440-1065 = -217±2; p<0.01; control (without manipulation): -216±2 mV. GSH: 0-270 = 29±1; 440-1065 = 30±1; control = 36±1 nmol/mg prot. GSSG: 0-270 = 0.82±0.08; 440-1065 = 0.38±0.04; p<0.01; control = 0.49±0.07 nmol/mg prot. Alveoli: 0-200 = 26±1; 270-1065 = 30±1; p<0.01; control = 33±2 count/mm.

Discussion: Addition of glutathione in PN allows detoxification of peroxides (lower GSSG), preventing oxidation of redox and loss of alveoli. A clinical study is expected to start soon

Biography:

Hyunsook Kim is an expert in the development of new functional natural food ingredients as an effective means of managing weight and decreasing risk factors for obesity and related metabolic diseases. She adds value in byproduct waste from fruit and vegetable processing and also potentiates their effectiveness after combined with probiotic lactic acid from fermented foods. Using high-throughput techniques including nutrigenomics, metabolomics, metagenomics, and biochemical analysis, she is trying to determine novel pathways and bioactive components involved in intestinal microbiota, innate immunity, inflammation, intestinal permeability, lipid metabolism, gut-derived hormones, adipose-derived hormones that improve obesity and related metabolic disease

Abstract:

The objective of this study was to determine, if combination of prebiotics (whole wine grape seed flour) and probiotics (kefir-derived lactic acid bacteria, LAB) could induce synergistic synbiotic anti-obesity effects on obese mice. Grape seeds are high in polyphenols, including flavonols, particularly proanthocyanidins. Mice were fed either with a high fat (HF, 47% fat calorie) or chow diet for five weeks. Mice on the HF diet that were greater in weight than mice fed with chow were considered diet induced obese (DIO). The DIO mice were fed with the HF or HF diet supplemented with 5% or 10% Chardonnay grape seed (ChrSd) flour in the combination of kefir-derived lactic acid bacteria for 8 weeks. Continued feeding of the HF diet supplemented with ChrSd and LAB resulted in significant decrease in weight gain, liver weight, adipose weight, and plasma and hepatic lipid levels. ChrSd and LAB significantly improved insulin sensitivity. These changes were more profound by combination of ChrSd and LAB. Possible mechanism may be related to enhanced bioavailability of proanthocyanidins by action of probiotic lactic acid bacteria in the intestine. These results suggest that combined ingredients of ChrSd and LAB are effective to reduce HF-induced obesity and insulin resistance. These synergistic effects could solve a problem that a large amount of prebiotics or probiotics intake requires to exert similar health beneficial effects

Biography:

Jessy El Hayek joined the Department of Nursing & Health Sciences at Notre Dame University in Fall 2012 shortly after completing her PhD and Postdoctoral Fellowship in Human Nutrition, in McGill University, Canada, in March 2011. Currently, she is teaching multiple graduate and undergraduate courses including basic human nutrition, lifecycle nutrition as well as community nutrition. As of September 2014, she was appointed as Chairperson of the Department of Nursing & Health Sciences

Abstract:

This study aims to examine the effect of dietary, socio-demographic and lifestyle factors on body composition among students from Notre Dame University. In this cross-sectional study, socio-demographic, lifestyle, anthropometric variables including body composition (soft lean mass (SLM), percent body fat (PBF), and visceral fat area (VFA)) were collected. Stress was assessed through the perceived stress scale (PSS). Diet was assessed through MEDFICTS. Out of 392 students, 3.1% were underweight, 59% were normal, 40% were overweight and obese. In women, 10.5%, adhered to the Therapeutic Lifestyle Changes (TLC) compared to men (2.5%), while 52.5% of men needed dietary changes compared to 39.5% of women, (p<0.01). Men who adhered to TLC were in the first tertile of PBF. Participants in the first tertile of PBF/VFA/SLM had the lowest waist circumference (WC), BMI, and highest fitness score. Only men in the first tertile of SLM had the highest waist to height (WHt). Smoking was associated with PBF in men only. Total number of hours of sleep was not associated neither with PBF/SLM in both genders nor with VFA in women, while men in the first VFA tertile slept more (7.5 hours) than those in the third tertile (6.9 hours) (p<0.01). Even though the majority of the sample was of normal weight; most men were overweight or obese. The association between lifestyle and dietary factors and body composition was not similar across genders; accordingly, it is important to provide gender based nutrition interventions in universities

Biography:

Wei Ney Yap (PhD) earned her degree from University of Singapore. She is now the Section Head of Biological section at Davos Life Science Pte Ltd. She has more than 10 years’ research experience in tocotrienols (a palm oil derived natural vitamin E), specifically the benefits and mechanism of actions of this lipid soluble vitamin in human health and nutrition. Her research work has received Educational Fellowship Award from the European Academy of Dermatology Venereology (EADV) in 2014. Moreover, the company she is currently working with has previously received 2010 Asia Pacific Frost & Sullivan Excellence in Research Award in the Natural Vitamin E Market

Abstract:

Tocotrienol (T3) is the other half of the vitamin E family. Like tocopherol (TP), T3 provides antioxidant protection to all living cells. T3 and TP share similar chemical structures in the chromanol ring but differ from their side chains. Each T3 and TP has four homologues: Alpha (α), beta (β), gamma (γ), and delta (δ) depending on the number and location of methyl groups on the chromanol ring. T3 and TP are closely related yet vary widely in their effectiveness inT3 is shown to possess up to 60 times more superior anti-oxidative activity compared to TP. In addition, T3’s distinct chemical structure gives it more fluidity, enabling its cellular uptake in biological systems to be up to 70 times higher than TP. The naturally occurring T3 is scarce in nature. They are found abundantly in crude palm oil extract. Other sources are from rice (bran), annatto and wheat. Toxicology and pharmacology studies showed that supplementation with palm based T3 up to 2500 mg per kg of body weight did not cause any significant adverse effects. A growing awareness of T3’s distinct health benefits has fuelled an increasing number of research studies worldwide, despite TP is regarded as the more common vitamin E in the market nowadays. Cumulative in vitro, animal models and human clinical trials have convincingly shown that T3 possesses biological activities such as anti-inflammatory, anti-cancer, balancing cholesterol lipid profiles, neuroprotection, anti-cancers and other biological activities. All these benefits are not seen in TP. Increasing health concerns among the aging population coupled with the health awareness benefits either in acute or chronic diseases is expected to drive T3 demand in dietary supplements. Antioxidation property of T3 is expected to spur product demand in personal care & cosmetic industry. In addition, cholesterol and lipid lowering characteristic is expected to drive T3’s demand in nutraceutical and pharmaceuticals industries

Biography:

Paola Bontempo has completed Medical Education in Medicine and Surgery in 1991 from University of Naples Federico II. She obtained license to practice medicine in 1991. In 1997, she did a specialization in Clinical Pathology at Second University of Naples. In 2003, she completed PhD in Cellular and Molecular Pathology from University of Naples Federico II. In 2004, she joined as Researcher in the Department of General Pathology at Second University of Naples. From 2005 till date, she is working as Aggregate Professor in the Department of Biochemistry, Biophysics and General Pathology, Second University of Naples. She currently teaches Clinical Pathology and General Pathology at the Second University of Naples Medical School. She is actively involved in studies concerning the mechanism(s) of proliferation, differentiation and apoptosis induced by steroid hormones, epigenetic modulators and natural compounds in cancer systems

Abstract:

Epidemiological analyses suggest that individuals consuming a diet rich in fruits and vegetables have a reduced risk of developing non-communicable diseases such as cancer. Solanum tuberosum L. var. Vitelotte is a potato variety with deep blue skin and violet flesh widely used for human consumption and well appreciated for its good nutritional characteristics. The pigments responsible for its attractive color belong to the class of anthocyanins. The purpose of this study was to analyze the biomedical activities of anthocyanins extract derived from the Solanum tuberosum. The main objectives were to characterize and measure the concentration of anthocyanins in pigmented potatoes, and to evaluate their antioxidant, antimicrobial activities and their anti-proliferative effects in solid and hematological cancer cell lines. Molecular genotyping was performed to properly identify this outstanding genotype in comparison to other potato varieties and to promote the utilization of this genetic resource by plant breeders. Anthocyanins exert anti-bacterial activity against different bacterial strains and a slight activity against three fungal strains. The Gram-positive bacterium Staphylococcus aureus and the fungus Rhyzoctonia solani were the most affected microorganisms. Antioxidant activities were evaluated by DPPH and FRAP methods; the extract showed a higher reducing capability than anti-radical activity. In different cancer cell models, the anthocyanins cause inhibition of proliferation and apoptosis in a dose dependent manner. Furthermore, cellular and molecular characterization of the action of anthocyanin extract in cancer cells revealed that modulation of cell cycle regulators occurs upon treatment. As well as inducing apoptotic players such as TRAIL in cancer systems, anthocyanin extract inhibited Akt-mTOR signaling, thereby inducing maturation of acute myeloid leukemia cells. These biological activities are likely due to the high content of malvidin 3-O-p-coumaroyl-rutinoside-5-O-glucoside and petunidin 3-O-p-coumaroyl-rutinoside-5-O-glucoside. These results are of interest in view of the impact on food consumption and as functional food components on potential cancer treatment and prevention

Biography:

L Akhalbedashvili she has completed her higher education from Ivane Javakhishvili Tbilisi State University, Georgia

Abstract:

At valuation security of wines, special role should be given to analytical control of pollutants, such as heavy metals (HM) which potentially have toxic and carcinogenic properties. So, important is the determination of their content in wines and assessment of effect on threshold of their toxicological effects on living organism. Contents of HM in wines depend on type of soil, processing conditions of vineyard, climatic conditions, vinification, anthropogenic factors and so on. In work, first, the migration of heavy metals Pb, Cu, Zn, Cd, Co, Ni, Mn, Fe in a chain: soil→stem→skin→pulp→wines Kindzmarauli and Saperavi from unique vineyards Mukuzani and Sabue of Kakheti region of Georgia were studied. All solid samples were treated by method of dry mineralization. To determine the HM content in samples, atomic absorption spectrophotometry (Perkin-Elmer Analyst 200) was used. With increasing depth of soil from 5 to 50 sm HM contents decreased in Mukuzani vineyard: Cu from 53.65 till 42.6mg kg^-1 in and Zn from 78.5 to 67.1mg kg^-1, but in cleaner region-Sabue vineyard, content of all elements studied increased a little with increasing depth. In chain, soil →stem→skin→pulp →wines, the quantity of HM decreased, more than an order, but non-uniquely. In leaves, content of Cu and Fe in 5-10 times prevail their content in soil and skin, in juice and wine decreased in hundred times. It is known that the use of copper containing fungicides for the disease control of plants could also lead to increase in the Cu amounts of grapes, as well as of the products obtained from their processing. But in Georgian wines, the content of all HM not prevails 0.2 mg/l.). Most of HM in the grapes precipitates during fermentation into sediments, which is the reason for their significantly lower content in the wine

Biography:

Roni Lara Moya completed his Bachelor’s in Biomedicine from University of Mogi das Cruzes, Sao Paulo and a Specialization in Anti-Aging Medicine from Seville University, Spain. He completed Master of Science in Molecular and Cellular Immunology and Biology in University of Coimbra, Portugal and a Master of Science degree in Clinical Advanced Nutrition, University of Barcelona, Spain and PhD in Biomedicine and Immunology, Gulbenkian Institute of Science and Coimbra University. He is a Coordinator of Orthomolecular Medicine of ReGenera Research Group for Aging Intervention. He is a Professor and Director of the Graduation Program in Orthomolecular Therapy, CESPU University, Portugal and Scientific Advisor for Nutraceuticals and Cell Therapy Companies in Europe

Abstract:

Despite all efforts and scientific development in cancer research and treatments, the corresponding estimates for total cancer deaths in 2012 were 8.2 million (about 22,000 cancer deaths a day) – 2.9 million in economically developed countries, and 5.3 million in economically developing countries. By 2030, the global burden is expected to grow to 23.6 million new cancer cases and 13 million cancer deaths imply due to the growth and aging of the population. However, the estimated future cancer burden will probably be considerably larger due to the adoption of lifestyles that are known to increase cancer risk, such as smoking, poor diet, obesity, physical inactivity, chronic inflammatory diseases, etc. Cancer can actually be defined by a group of diseases characterized by the interaction between abnormal cells with its natural environment, resulting in uncontrolled growth and spread of these abnormal cells. If the spread is not controlled, it can result in death. Cancer is caused by external factors, such as tobacco, toxins, infectious organisms, an unhealthy diet, and internal factors, such as inherited genetic mutations, hormones, and immune conditions, may act together or in sequence to cause cancer. One of the most important problems in oncology is the immunological compromising due to the ability of cancer cells to thrive in a chronically inflamed microenvironment, evade immune recognition and suppress immune reactivity. In consequence, the chronic inflammation and extreme oxidative stress, will allow an enhancement of genomic instability, DNA damage, epigenetics change, apoptosis evasion, metastasis, etc. Some important functional nutrients with specific antioxidants and polyphenols, together with purified cellular derived peptides and mitochondrial extracts, rich in inmunomodulator factors, work on innate or acquired immunity. They stimulate fundamental organs as the thymus, spleen and bone marrow, regulating the transcription, apoptosis, oxidative stress, the activation of dendritic cell, B lymphocytes CD4, CD8, and Natural Killer (NK); as well as the production of its main cytokines (IFN, T NF, IL4, etc.). The purpose of this conference is to address the clinical practical aspects and protocols based on the most relevant scientific studies of integrative biomedical treatments with the best functional nutrients and cellular derived extracts as potent inmunomodulators in cancer cases. Besides the increase in conventional treatment techniques and pharmaceuticals, there is also an eminent and continuous need to seek the best and smartest integrative biomedical and nutritional treatment to help prevent and fight cancer

Biography:

Vivienne Lewis is a Clinical Psychologist, specialising in the area of body image and eating disorders both in her clinical practice and in her research at the University of Canberra, Australia. She is the author of “Positive Bodies: Loving The Skin You’re In” a self-help book for people, including both men and women, with body image issues. She also recently released a guide for health profressionals working with people with body image issues and eating disorders called ‘No Body’s Perfect’. Both of these books are published through Australian Academic Press. She is actively involved with many government eating disorder and body image services promoting the celerbation of body acceptance and diversity. She is a Committee Member for the professional body, the Australian Psychological Society College of Clinical Psychologists

Abstract:

Body image satisfaction is important, particularly for females, in terms of positive mental health. A healthy body is part of a health body image and perception of self. We know that a poor body image is a key diagnostic criterion for eating disorders and is related to engagement in eating disordered behaviour and poorer mental health. Working with people with body image issues and eating disorders is complex and sensitivity is needed. Eating disorders are severe and complex conditions that often require expertise in order to work effectively with this client group. This presentation is a guide to health profressionals, including dieticians and nutritionists as to how to work with adults presenting with body image issues and eating disorders. The author will draw on her experience as a researcher and clinican having worked with many people of all ages and both genders presenting to her as a clinical psychologist

Biography:

Silvia Martina Ferrari graduated in Biological Sciences cum laude in 2002 and specialized in Clinical Pathology in 2007 at the University of Pisa (Italy). Her principal areas of expertise are autoimmune thyroid disorders, chemokines and cytokines, type 1 diabetes, systemic autoimmune disorders, HCV-associated thyroid disorders and thyroid cancer. Her researches have been published in more than 140 articles in international journals (HI=37). She serves as an Editorial Board Member and is Referee and Reviewer of many scientific international journals

Abstract:

Myo-inositol has a determinant role in different metabolic pathways. Experimental data and clinical trials showed that myo-inositol and phosphatidylinositol(s) are involved in physiological and pathological conditions of the thyroid. Phosphatidylinositol is important in the intracellular signaling associated with thyroid-stimulating hormone (TSH) pathway in thyrocytes, and it is involved in thyroid autoimmunity. Recently it has been demonstrated the beneficial effects obtained by myo-inositol in association with seleno-methionine in patients affected by subclinical hypothyroidism. The myo-inositol effectiveness on TSH could be explained by its biological role in the TSH hormone signaling, as inositol regulates the H₂O₂-mediated iodination and the impairment of inositol-depended TSH signaling pathway can cause TSH resistance, and hypothyroidism. For this reason, the therapy can increase the amount of the second messenger, improving the TSH sensitivity. Moreover, it seems that myo-inositol could have promising therapeutic effects in insulin resistance, metabolic syndrome and their related disorders [diabetes, polycystic ovary syndrome (PCOS)], autoimmunity and certain malignancies, and their links. Further studies on the inositol pathways involved in certain disorders could lead to hypothesize additional therapeutic applications

Biography:

L A Almousa has completed her Doctorate program in Human Nutrition from College of Food & Agricultural – King Saud University in 2012, Master’s in General Nutrition from Prince Nora University in 2007 and Bachelor’s degree in Nutrition and Food Science, Prince Nora University in 2002. At present, she is studying for a PhD degree at the University of Nottingham (UK)

Abstract:

Magnesium has anti-inflammatory and antioxidant effects, and it has a defensive role in triggering the body’s immune cells. Moreover, magnesium enhances endothelial function and inhibits atherosclerosis. Inflammation is a risk factor for atherosclerosis progression and can be mediated by nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation, which plays a key role in the development of inflammation because when NF-κB transfers to the nucleus and binds to promoter regions, it initiates the transcription of many inflammatory mediators. In response to inflammation, NF-κB enhances the transcription of Intercellular Adhesion Molecule-1 (ICAM-1), Vascular Cell Adhesion Molecule-1 (VCAM1) and inflammatory cytokines, which aid in the transmigration of leukocytes from the blood vessel lumen through the barrier of the endothelial cells and into the subendothelial space. In this study we determined the effect of different concentrations of magnesium on the expression of NF-κB. HUVECs were cultured in different MgSO₄ concentrations: 0.1 mM, 5 mM and compared to the physiological circulating concentration (1 mM). Expression of NF-κB was determined at the mRNA level by quantitative real-time PCR. Significantly elevated NF-κB expression was observed in magnesium-deficient (0.1 mM) cells that were stimulated with lipopolysaccharide 0.5 µg for 4 hours (34%, P=0.032), Moreover, a marked suppression of NF-κB expression in the magnesium-treated (5 mM), LPS stimulated HUVECs was observed (31%, P=0.048), relative to the 1 mM physiological concentration. These data shows that magnesium was inversely associated with the expression of NF-κB which induces an overexpression of the inflammatory phenotype in endothelial cells and has been connected to the pathogenesis of many cardiovascular diseases

Biography:

Poupak Fallahi graduated in Medicine and Surgery in 1993 and specialized in Occupational Health Medicine in 1999 at the University of Pisa (Italy). Her principal areas of expertise are autoimmune thyroid disorders, Type 1 diabetes, chemokines and cytokines, systemic autoimmune disorders, HCV-associated thyroid disorders and thyroid cancer. Her researches have been published in more than 200 articles on International journals (HI=46). She serves as an editorial board member and is Referee and Reviewer of many scientific International journals

Abstract:

Different human diseases, as cancer, impaired immune function, neurodegenerative and age-related disorders and disturbances of the thyroid hormone axis, are related to an insufficient supply of the essential trace element selenium. For example, its deficiency, in combination with inadequate iodine, is involved in the pathogenesis of myxedematous cretinism. Selenium naturally occurs in an inorganic (mineral or metallic) or organic form (selenomethionine and selenocysteine), and its biological action is exerted through selenoproteins. The thyroid gland has the highest selenium content per gram of tissue of the whole body.  in cellular antioxidative defence systems and redox control [the glutathione peroxidase (GPx) and the thioredoxin reductase (TxnRd) family] contribute in protecting the thyroid from an excess of hydrogen peroxide and reactive oxygen species, derived from the biosynthesis of thyroid hormones. Moreover, the three major enzymes involved in activation and inactivation of thyroid hormones are selenoproteins. Serum selenium concentrations decrease in inflammatory conditions and can vary according to the severity and duration of the inflammation. For this reason, the effect of selenium supplementation seems to be useful. Moreover, selenium is able to improve the activity of T cells and the cytotoxicity of natural killer cells, resulting efficacious in viral diseases. However, whether selenium supplementation is effective in patients with Hashimoto Thyroiditis is still not clear, even if it seems advantageous in cases of mild/moderate Graves’ Orbitopathy. In conclusion, further studies are necessary to evaluate whether selenium supplementation could be effective in autoimmune thyroid disorders

Biography:

Stefania D’Adamo is a Molecular Biologist and Post-Doctoral Fellow in Flamigni’s Lab at University of Bologna working on nutraceutical role in the modulation of some dysregulated pathways implicated in chronic and degenerative pathologies, including cardiovascular and osteoarthritis diseases. She has opened a new research line in her lab that focuses on exploring the epigenetic connections between nutraceuticals and defective processes associated to aging

Abstract:

Osteoarthritis (OA) is the most frequent degenerative pathology of joints leading to pain and loss of function for many patients, in particular the elders. Aging has been proposed as the main risk factor of this pathology, followed by obesity. The real hub between aging changes in cells and proneness to OA seems to be found in the role of cell senescence. This phenotype can be associated to an over production of reactive oxygen species (ROS) due to defective mitochondrial function and up-regulation of inflammatory pathways that participate in the “aging stress response”. However lack of efficacy in current pharmacotherapy is spurring scientific community to spend efforts and resources to unveil new molecular targets and alternative therapies. Nutraceuticals have been shown to exhibit a role not merely as anti-oxidant or ROS scavengers, but also as efficient modulators of gene expression of key factors underlying the OA onset. The most commonly used dietary supplements and the recent scientific evidence on novel natural compounds supporting the efficacy for OA treatment and prevention will be discussed. In particular, I will pay attention to a promising nutraceutical, 3- hydroxytyrosol (HT). It is a phenolic compound, endowed of a powerful anti-oxidant action, mainly found in the fruits of olive tree (Olea europaea L.) and their derivatives, such as olive oil. Our recent findings have shown HT as a potent promoter of autophagy flux and autophagy-related gene expression. Then, we demonstrated that HT can modulate the longevity factor Sirt1, by modulating microRNA (miR) network. The image on the right represents the molecular mechanisms by which HT can exert protection against oxidative stress-induced cell death in chondrocytes. This evidence suggests that HT can be considered in the future as an adjuvant nutraceutical in OA therapy

Biography:

Carla Sillitti is a PhD student of the University of Foggia. She is carrying out her PhD work in collaboration with CNR-ISAFOM in Catania. She has completed her Master’s in Health Biology. She is developing a project to produce new nutraceutical food, a type of pasta, based on the use of ancient Sicilian whole meal and inulin. Many studies were carried out to define the best type of semolina and inulin to be added. She is interested in nutraceutical food and food quality, as well as nutrition and human health

Abstract:

Statement of the Problem: The ancient Sicilian whole meal grains, re-evaluated as the basis of the Mediterranean diet, are rich in fiber and vitamins and matched the inulin consumption contribute to lower the glycemic index of pasta produced, representing a good source of carbohydrates for diabetics. Currently the inulin added to foods is extracted from chicory (~20 fructose units). The aim of the study was to evaluate the quality of pasta obtained by ancient Sicilian whole grains semolina with inulin extracted from roots of cardoon (~80 fructose units).

Methodology & Theoretical Orientation: Four cvs of whole meal flour durum wheat (Russello, Senatore Cappelli, Margherito and Timilia) were used for the production of spaghetti with 2 types of inulin extracted from roots of both chicory and cardoon, in 2 and 4% (w/w). A commercial durum wheat semolina was used as a control. Pastas produced were evaluated for color (Minolta colorimeter CR, 400), cooking time (minutes), quality and loss of inulin (HPAEC-PAD, Thermofisher) in cooking and sensory qualities (Panel).

Findings: On average of 4 varieties, the overall quality of the spaghetti was 6.5 compared with 5.9 of the control. The values increased with the addition of 2% (w/w) of inulin, in fact the cv “Russello” and “Senatore Cappelli” showed values of 6.8 and 6.6 respectively, compared with the control (6.5). With the highest concentration of inulin showed highest interaction with the cv used. “Margherito”, “Timilia” and “Senatore Cappelli” showed higher values with cardoon inulin, although “Russello” and “Senatore Cappelli” decreased their values with the addition of chicory inulin. On average of 4 varieties, the addition of inulin from cardoon resulted in an increase in the index L*, perceived positively during the panel test. Different types of semolina have influenced mainly the cooking loss.

Conclusion & Significance: Further tests are underway to define the optimal concentration of inulin to add and the best type of semolina to use

Biography:

Kimia Moiniafshari has received her BSc degree in Nutrition field from Shahid Beheshti University of Medical Sciences and is MSc student in Sport Nutrition field. She is Nutrition and Autism Researcher and her BSc thesis was about management of nutritional strategies for preventing and controlling autism, and has some publications in this area and now is working on athlete's metabolism and effective supplements for improving their exercise performance

Abstract:

Vitamin D deficiency is common among athletes depending on their skin color and indoor exercise time. Vitamin D is a vital component in biological reactions in human. Scientific articles have shown that vitamin D supplementation has positive effects on athletes’ performance. Besides that, omega-3 fatty acids (FA) play supportive role on athlete's cardio-vascular system. The purpose of this review article was to evaluate the effect of vitamin D and omega-3 FA supplementation on muscles, aerobic capacity, exercise performance and cardio-vascular system in athletes. Among the total 40 articles including entrance criteria, 19 articles including 13 original and 6 review articles were analyzed. Vitamin D plays important roles in synthesis of proteins, hormones, gene expression regulation and muscular performance. Vitamin D deficiency increases the risk of fractures, inflammation, infection and prolonged recovery time. Furthermore, vitamin D increases calcium availability and improves cross bridge cycle and muscular contractions. Decreased level of vitamin D lower than 30 nmol/lit leads to reduced exercise power and increases the risk of infections, Omega-3 FAs improves cardio-vascular function via nitric oxide production and also leads to less total oxygen consumption, lower heart rate and muscular oxygen requirement. Researchers have suggested that omega-3 Fas supplementation increases the level of ecosapanthanoic acid (EPA) in erythrocytes and decreases the peroxidative erythrocyte's protein destruction which results in oxidative balance. Vitamin D and omega-3 Fas supplementation have beneficial effects on athletes’ performance and doses higher than physiological daily intake may be needed according to increased requirement and deficiency prevalence in athletes

Biography:

Neslihan Arslan graduated from Yeditepe University. She started pursuing Master's degree at Gazi University. Her Master’s education is still ongoing and also works as a Research Assistant at Gazi University

Abstract:

Diet and nutrition are among the most important factors in coronary artery disease. Many epidemiological studies have reported that antioxidant intake from diet is associated with a lower risk of coronary artery disease (CAD). This study was designed to assess the nutritional status and dietary antioxidant capacity of patients with CAD. The sample of study with 18 patients with angiographically documented CAD and 18 healthy controls was included into study from Atatürk Education and Research Hospital Ankara, Turkey. The ethical approval was taken from Zekai Tahir Burak Hospital from Turkey. A questionnaire regarding clinical, biochemical, dietary, family history, demographic and socioeconomic status was conducted by the researcher. Nutritional status was assessed by antropometric measurements and calculating Body Mass Index (BMI, kg/m²). The serum glucose, HDL-Cholesterol, LDL-Cholesterol, Total Cholesterol, Triglyceride, AST, ALT, Creatinine, Urea, Sodium and Potassium was obtained from the records of Cardiology Clinic of Atatürk Education Research Hospital. The dietary intake was assessed by using 24-hour dietary recall method by the researcher. Dietary antioxidant capacity was calculated from an article which calculated the antioxidant capacity of 3100 foods. The results represented that mean age was 53.6±7.3 years in patient group, 51.9±8.31 years in control group. The mean body weight was 82.95±16.56 in patient group, 84.5±10.20 in control group. Although not statisticaly important the mean waist circumference, hip circumference, neck circumference and body mass index is higher in patient group than control group. The mean triglyceride was significantly higher in patient group than control group (p<0.01). The mean dietary antioxidant capacity did not differ between patient and control group. It is a negative correlation between coronary artery disease grade and dietary antioxidant capacity in patient group. Inverse association was observed between dietary antioxidant capacity and triglyceride levels in both groups. In conclusion, antioxidant intake is very important to minimize the effects of coronary artery disease. Both coronary artery disease patients and healthy individuals should be given importance to antioxidant intake in order to protect from both disease and their effects

Biography:

Hazal Kucukkaraca has graduated from Hacettepe University, Faculty of Health Sciences Department of Nutrition and Dietetics in 2014. She has been working as a Research Assistant at Ondokuz Mayis University, Faculty of Health Sciences, Department of Nutrition and Dietetics since 2015. She is continuing her graduate studies in Nutritional Science

Abstract:

The aim of study was to evaluate the relationship of serum paraoxanase1 (PON1) activity, total oxidant (TOS) and antioxidant (TAS) status with inflammation in hemodialysis patients. 23 patients (diagnosed with hemodialysis) and 27 healthy volunteers were included in study (18-75 years). Rel Assay diagnostics kits were used to determine PON1, arylesterase (ARES), TAS, and TOS in individual serum samples. PON1 and ARES were found to be low in hemodialysis patients. PON1 were determined to be low in 87% of study group and 33% of control group. Individuals who have high PON1 activity were found to have high levels of ARES and HDL (p<0.05). When all subject’s PON1 activity and lipid profile were assessed, PON1 activity had strong positive correlation with HDL, negative correlation with LDL and cholesterol (p<0.05). Negative correlation was observed between CRP and PON1, ARES and TAS, but positive correlation with TOS (p <0.05). CRP levels of hemodialysis patients were 11.7±15.9 mg/L, PON1 values were found to be low in 88% of patients with inflammation. TAS were below normal levels in 91.3% of study group and 70% of control group. However, in all of control group and 86.9% of study group’s TOS were normal. Significant differences were found between PON1, TAS and TOS. Finally, low PON1 activity in hemodialysis patients is associated with reduction in antioxidant capacity of HDL, thereby causing atherosclerosis and inflammation. While decrease in oxidants in hemodialysis patients is though positively, decrease in antioxidants is unwanted. Therefore, TAS and TOS levels are important in terms of immunity and metabolic disorders

Biography:

Gul Eda Kilinc has graduated from Gazi University, Faculty of Health Sciences, Department of Nutrition and Dietetics in 2014. She has been working as a Research Assistant at Ondokuz Mayis University, Faculty of Health Sciences, Department of Nutrition and Dietetics since 2016

Abstract:

The aim of this study was to evaluate the effect of sleeve gastrectomy on the post-op body analysis and laboratory findings. During January 2016-2017, 101 morbid obesity patients (18-65 years) who underwent sleeve gastrectomy were evaluated in Nutrition and Support Unit. Clinical findings of patients were retrospectively analyzed, pre-op and post-op body analysis and laboratory findings were compared. Among the 101 individuals (82 female and 19 male), average age was 38.0±10.9 years. Pre-op weight and BMI values are average respectively 130.0±18.6 kg, 48.9±6.9 kg /m²; post-op average 115.8±18.3 kg, 43.4±6.8 kg/m² (p<0.05). Respectively, pre-op and post-op (0-3 months) body fat percentages are 29.8-55.9% and 24.1-51.7% of women, 32.6-45.4% and 20.4-41.4% of men (p<0.05). When pre-op and post-op biochemical findings were compared, blood glucose, total protein and albumin levels were decreased (p<0.05). While total cholesterol in blood lipids decreased in post-op period (p<0.05), there was no significant change in HDL and LDL. Post-op vitamin-mineral values was compared, the decrease in folate values was significant, the decrease in vitamin B₁₂ levels wasn’t significant. Although the decrease post-op iron levels and increase in calcium weren’t significant, increase in phosphorus, sodium, potassium and chlorine values was significant. Changes in vitamin D levels weren’t significant. Consequently, bariatric surgery is an effective method for achieving weight loss in morbid obese patients. It is important for the recommendation of supplements to prevent vitamin-mineral deficiencies and providing adequate and balanced nutritional behavior changes in the post-op period

Biography:

Fatima Alzain Adam Adeela has BSc and MSc in Family Science (Health and Therapeutic Nutrition from University of Khartoum, and a Postgraduate Diploma in Diabetes Education from Ahfad University for Women. She attended Sudan International Diabetes Congress in 2016 (SIDC 2016)

Abstract:

Background: Type 2 diabetes is one of the most challenging medical disorders because of the demands it imposes on day to day life. Good glycemic control (GC), as judged by GbA1c, fasting serum plasma glucose (SPG) and random (SPG) levels. Diet plays a major role in the overall management of type 2 diabetes.

Purpose: The purpose is to assess the effect of Dietary Advice (DA) on glycemic control in patients with type 2 diabetes and to determine long-term and short-term complication of diabetes by low dietary carbohydrate advice on metabolic control and quality of life in patient with type 2 diabetes.

Research Design & Methods: Randomized patients attending a diabetes education clinic at primary health care centers were included. The study targeted a total number of 99 cases (35 male – 76 female) of type 2 diabetes aged between 20–80 years. Depending on the treatment of oral hypoglycemic agents subjects measured (SPG) for fasting and (SPG) for random, weight and height for body mass index (BMI) before and after intervention.

Outcomes: Medical outcome measures the change of glycemic control among the target group before and after the nutrition education.

Results: After the intervention period of 12 months, subjects have shown significant lower circulating levels of (SPG) for fasting which is 49%, levels of (SPG) for random which is 51.5% and a reduced body weight.

Conclusions: DI positively modulates the GC without increasing the risk of hypoglycemia and enhances the quality of life in patient with type 2 diabetes