Hitoshi Adachi
Prefectural Cardiovascular Center, Japan
Title: Effect of restricting ice cream intake at night on insulin sensitivity and cardiac function
Biography
Biography: Hitoshi Adachi
Abstract
Statement of the Problem: Free fatty acid production from triglyceride is well known to induce insulin resistance, which is reported to be one of the causes of cardiac dysfunction in patients with dyslipidemia. Nocturnal monosaccharide over taking causes hyper triglyceridemia and with holding it is supposed to reduce fasting triglyceride levels. And as a result, there is a possibility that cardiac dysfunction would improve. Hereby, we investigated the effect of restriction of night-time ice cream intake on insulin resistance and cardiac function.
Method: Thirteen patients with cardiac dysfunction who routinely take ice-cream at night were enrolled. We instructed them not to eat ice cream after 21 o’clock for 3 months, and compared the HOMA-IR, blood triglyceride level, exercise tolerance (peak VO2 and anaerobic threshold) and diastolic cardiac functions before and after the examination.
Findings: Triglyceride level and HOMA-IR significantly improved from 217.2+-63.1 to 150.2+-37.7 mg/dL (p<0.01), and 4.5+2.0 to 2.4+-2.3(p<0.05) respectively. Although, E/A failed to improve, E/E’ and DcT improved significantly from 10.1+-3.0 to 8.1+-2.3(p<0.01) and 241+-65 to 231+-50(p<0.05), respectively. Peak oxygen uptake and anaerobic threshold improved significantly.
Conclusion & Significance: It is concluded that restriction of nocturnal ice-cream improves cardiac function by ameliorates insulin resistance.