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24th International Conference on Clinical Nutrition

Barcelona, Spain

Yoav Sharoni

Yoav Sharoni

Ben Gurion University of the Negev, Israel

Title: Preclinical and clinical studies with tomato carotenoids to balance blood pressure and skin health

Biography

Biography: Yoav Sharoni

Abstract

Several human studies have shown that tomato carotenoids can affect various aspect of human health. In this presentation the author will address two issues – a) balancing the response of skin cells to UV irradiation and b) the reduction of elevated blood pressure. a) Several human studies have shown that tomato carotenoids can reduce UV-induced damage by reducing erythema and improving the balance between collagen production and breakdown. We hypothesized that a combination of tomato carotenoids with polyphenols may produce better skin protection than that expected from summation of their activity. Indeed, we found that combinations of tomato nutrient complex (containing lycopene) with rosemary extract (containing the polyphenol carnosic acid) synergistically reduced inflammatory markers and inducedm antioxidant activity in skin cells leading to reduction of Matrix Metalloproteinases (MMPs) and thus may reduce collagen breakdown and delay skin ageing. b) Essential hypertension is a risk factor for cardiovascular morbidity and mortality. We performed a dose-response analysis to uncover the optimal effective dose of a tomato nutrient complex supplement in maintaining normal blood pressure among hypertensive individuals. Results indicate that treatment for 8 weeks with tomato nutrient complex standardized to contain 15 mg or 30 mg of lycopene was associated with significant reductions in systolic blood pressure. Treatment with lower dose or treatment with 15 mg of synthetic lycopene as a standalone did not show a significant effect. The human bioavailability of the major tomato carotenoids lycopene, phytoene and phytofluene was dose-dependent following treatment with different doses of the tomato nutrient complex