Dina Keumala Sari
Sumatera Utara University, Indonesia
Title: Low serum 25(OH)D level in urban and rural women with vitamin D receptor gene polymorphism in North Sumatra, Indonesia
Biography
Biography: Dina Keumala Sari
Abstract
Background: Vitamin D deficiency found in women with vitamin D receptor gene polymorphism who lived in tropical country which is North Sumatera Indonesia. Most of vitamin D deficiency had associations with lifestyle, vitamin D intake and body weight.
Objective: This study investigated whether urban and rural women with vitamin D receptor gene polymorphism who lived in North Sumatera had difference circulating of 25(OH)D concentration and whether there are associations with other factors such as lifestyle, vitamin D intake and body mass index.
Design: This was a cross sectional study, including 100 healthy women with vitamin D receptor gene polymorphism, parameters observed were 25-hydroxyvitamin D serum; lifestyle including sunlight exposure, daily sunscreen application; vitamin D intake and body mass index.
Results: The prevalence of vitamin D deficiency was 70%, insufficiency was 29% and sufficiency was 1%. None of the subject reached normal 25(OH)D serum level. Mean of 25(OH)D serum level in urban women was 14.9±3.64 ng/dL and rural women was 20.24±4.43 ng/dL. The prevalence of routine daily sunscreen application was higher than not routine (87% vs. 13%), prevalence of less vitamin D intake was higher than enough vitamin D intake (83% vs. 17%) and prevalence of overweight was higher than normal and obese (83%, 12%, 5%, respectively). There was significant difference 25(OH)D serum level between urban and rural group.
Conclusions: The results indicated that vitamin D deficiency can occur in North Sumatera women and there was significant different between urban and rural group