Day 1 :
- Clinical Nutrition | Malnutrition | Clinical Nursing | Brain Nutrition | Trends in Nutrition
Mohammad Hussein Abnosi
Biology Department, Faculty of Sciences, Arak University, Arak, Iran
Title: The industrial pollution and the bone marrow mesenchymal stem cells: a serious concern for animal life
Mohammd Hussein Abnosi has opened a new line of research on chemical toxicity regarding the mesenchymal stem cells with respect to osteoporosis and the supplementary medicine using plats natural products such as catechin hydrates, curcumin, silymarin, Gallic acid and so on. He has started the research at 2009 and since then many scientific contributions was made to the scientific world. Throughout these years many students have been graduated under his guidance and started their own professional carries in different region of the world.
Statement of the Problem:
In industrial area a growing number of patients suffering from osteoporosis force us to fuscous on industrial pollution which is released in environment. The pollution enters human and animal body through air, water and food. Bone marrow mesenchymal stem cells (MSCs) are the cellular back up of osteoblasts, the cell responsible for bone matrix production which ensures the wellbeing of this tissue. MSCs are in intimate contact with peripheral blood and through which the industrial pollution are intoxicating the proliferation and differentiation ability of these cells. Proliferation of the MSCs confirms the constant presence, where their differentiation ability provides the animal with strong bone throughout the life. Based on our study the industrial pollution such as sodium arsenite, p-nonylphenol, di-2-ethylhexylphetalate, cadmium, diethaylamine cause the significant reduction of proliferation and differentiation ability of MSCs.
Methodology & Theoretical Orientation:
Using various analytical methods such as viability tests, population doubling number, colony forming assay, osteoblast matrix production assay, single cell gel electrophoresis, caspase activation analysis and gene expression study as well as oxidative stress investigation provided us with enormous data regarding the toxic effect of these pollutions on MSCs.
Our analysis revealed that the viability, proliferation ability and differentiation potential of these cells are wildly affected and the mechanism of these toxicity was also observed to be commonly based on induction of oxidative stress and apoptosis which arrest the cell cycle mainly at G1 stage via over-expression of P53 gene.
Conclusion & Significance:
Since the MSCs are playing important role in bone matrix production, their reduction of viability or proliferation bring about bone related complication mainly osteoporosis. As the induction of oxidative stress caused by these chemical can be controlled by natural products of plants, we strongly recommend the increase in daily consumption of plant product.
Department of Nutrition, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran
Title: Effect of ketogenic diet on cancer: A systematic review and meta-analysis of randomized controlled trials
I am Dr Adeleh Khodabakhshi, PhD of clinical nutrition and faculty member of Kerman University of Medical Sciences.
Background: In light of the mitochondrial metabolic theory, cancer could be considered a metabolic disease. It has been suggested that cancer metabolic therapies, including ketogenic diets (KD) may be useful to exploit differences in metabolism from non-neoplastic cells. In this systematic review and meta-analysis of randomized controlled trials (RCTs) we aimed to investigate the efficacy of KD as an adjuvant therapy in the treatment of cancer compared to a traditional non-ketogenic diet.
Methods: In this study, databases such as MEDLINE/PubMed, Web of Science, SCOPUS, EMBASE, and Cochrane Central Register of Controlled Trials were searched. Only RCTs that involved cancer participants that were assigned to dietary interventions including a KD group and a control group (any non-ketogenic dietary intervention) were selected. Two reviewers independently extracted the data, and the meta-analysis was performed using a fixed effects model or random effects model depending on the I2 value or p-value
Results: This meta-analysis showed a significant reduction in weight (WMD = -3.58 kg; 95% CI: -6.24, -0.92; P = 0.008, BMI (WMD = -1.96 kg/m2; 95% CI: -2.83, -1.09; P ˂ 0.001) and fat mass (WMD = -1.90; 95% CI: -3.57, -0.24; P = 0.025) with ketogenic diet. KD significantly decreased glucose (WMD = -9.52 mg/dl; 95% CI: -13.81, -5.23; P ˂ 0.001) and IGF-1 (WMD = -16.27 ng/ml; 95% CI: -22.44, -10.09; P ˂ 0.001). Furthermore, ketogenic diet induced ketosis by increasing β-hydroxybutyrate (WMD = 0.51 mmol/l; 95% CI: 0.11, 0.91; P = 0.012). There was a non-significant pooled effect of the ketogenic diet on insulin, C-reactive protein (CRP), lipid profile, kidney and liver function, and quality of life.
Conclusion: We found that KD might result in a greater reduction in glucose, IGF-1 , ketosis, weight, BMI and fat mass in cancer patients compared to traditional non-ketogenic diets. According to our data, additional well-designed RCTs with larger sample sizes are needed to evaluate if KD can be routinely used as an adjuvant therapeutic component in cancer patients.
Ahvaz Jundishapur University of Medical Sciences, Iran
Title: Effects of the Consumption of Black garlic on metabolic syndrome risk factors : A Double-Blind Randomized Controlled Trial
Essam Amerian is affiliated from Ahvaz Jundishapur University of Medical Sciences, Iran
Garlic (Allium sativum) has been used as a traditional medicine and home remedy since ancient times and in many cultures to treat various diseases and health problems. Global garlic consumption is declining. Some people do not like to eat raw garlic because of its pungent taste and smell. Therefore, attention was focused on the processing of this food in order to facilitate consumption and bring its taste closer to people's tastes. In this study, individuals were included in the study based on the definition of metabolic syndrome and were randomly divided into three groups of consumers, 2 and 4 grams of black garlic and the control group. Consumption of raw garlic in three experimental groups lasted for three weeks. Before and after the intervention, 5 cc of blood sample was taken to determine the level of blood glucose. Blood pressure and body mass index were also measured. Finally, statistical analysis was performed using one-way T-test using SPSS software version 25. The results of the average data show that consumption of black garlic, 2 and 4 grams, for three weeks has an effect on reducing all health indicators compared to pre-consumption values and the greatest effect is obtained with daily consumption of 4 grams of black garlic. Analysis of the results showed that there is a positive and significant relationship between consumption of black garlic and reduction of systolic and diastolic blood pressure and body BMI (p≤0.05). Meanwhile, for blood sugar, it was found that daily consumption of black garlic for 3 weeks of 4 grams (p≤0.0001) has a greater effect on lowering blood sugar than consumption of 2 grams of black garlic (p≤0.038). Based on the results of this study and similar studies, it can be concluded that black garlic can be used as a safe supplement to help prevent the development of health problems associated with metabolic syndrome.
Sara Abdelmuneim Abdelsalam
Ahfad University for Women, Sudan
Title: Evaluating the nutritional status of CA breast females undergoing chemotherapy (PG SGA sheet)
Sara Abdelmuneim, has graduated fom Ahfad University for women, khartoum Sudan. Bachelor degree holder in Nutrition and Dietetics, 2019. She has done her bachelor thesis in Nutrition status of CA breast females taking chemotherapy. she is research oriented and believe that nutrition is an updated field that needs major focus in nutritional studies and research especially nutritional oncology.
This purposively cross-sectional study aimed to evaluate the nutritional status of CA breast females on chemotherapy treatment. The reason why such topic has been chosen is, because of the notably increasing incidence of breast cancer through years. In addition to, the neglected nutritional concern upon oncology research area in Sudan. However, the study was conducted in Taiba Oncology center. A private center with highly professional Sudanese oncologist. The patients attending Taiba are all cancer patients undergoing one of the modalities of cancer treatment which is chemotherapy.
The research was validated using several nutritional assessment tools such as PG-SGA, NRI, BMI and 24hr recall. Parameters used were food dietary intake, biochemical data and anthropometric measurements.
Results reflected high percentages of malnutrition which were found among breast cancer females. Up to (75%) needed critical nutritional intervention that is, to conclude, hospitals and oncology centers should pay more attention to medical nutrition therapy for oncology patients and set nutritional protocols to improve both health and nutritional status among cancer